Press Releases

Cynapsus Therapeutics Has Article Published in Journal of Commercial Biotechnology

Marketwire, June 13, 2022

TORONTO, CANADA – Cynapsus Therapeutics (TSX-V: CTH) today announced that an article discussing its APL-130277 drug candidate will be published in the July 2012 Issue of the Journal of Commercial Biotechnology. The article titled “Creating systemic oral transmucosal drug delivery strategies: Case study of APL-130277” was co-authored by Anthony Giovinazzo, President and CEO of Cynapsus, Nathan Bryson, Chief Scientific Officer of Cynapsus, and Timothy Tankosic, Managing Director of Aqua Partners, LLC.

The July 2012 issue of the Journal of Commercial Biotechnology will be published on July 1, 2022 and distributed earlier at the BIO International Convention ( being held in Boston, MA, USA, from June 18 to 21, 2012.

The article broadly addresses the strategic application of systemic oral transmucosal (i.e., sublingual and buccal) drug delivery. The article also provides a specific discussion of the scientific, clinical and commercial considerations driving APL-130277, an easy-to-administer, fast-acting, oral reformulation of an approved drug, apomorphine, being developed to rescue Parkinson’s patients from “off” episodes. The principal advantages the oral transmucosal route and APL-130277 include: circumvention of first-pass hepatic metabolism in the gut, rapid onset of action, easy access via the oral cavity, easy administration for patients with dysphagia, and a high level of patient acceptance.

The full text version of the article is available at (Subscription Required), or by contacting Anthony Giovinazzo at [email protected].

The TSX Venture Exchange Inc. has not reviewed and does not accept responsibility for the adequacy or accuracy of this press release.

About Cynapsus Therapeutics

Cynapsus is a specialty pharmaceutical company developing an improved dosing formulation of an approved drug used to treat the symptoms of Parkinson’s disease. Over one million people in the United States and an estimated 5 million people globally suffer from Parkinson's disease. Parkinson’s disease is a chronic and progressive neurodegenerative disease that impacts motor activity, and its prevalence is increasing with the aging of the population. It is estimated that between 25 percent and 50 percent of patients experience off episodes in which they have impaired movement or speaking capabilities. Current medications only control the disease’s symptoms, and most drugs become less effective over time as the disease progresses.

Cynapsus’ lead drug candidate, APL-130277, is an easy-to-administer, fast-acting, oral reformulation of an approved drug, apomorphine, used to rescue patients from off episodes. Cynapsus is focused on rapidly maximizing the value of APL-130277 by completing pivotal studies in advance of a New Drug Application expected to be submitted in 2014. Cynapsus anticipates out-licensing to an appropriate pharmaceutical partner before such an application is submitted.

More information about Cynapsus (CTH: TSX-V) is available at and at the System for Electronic Document Analysis and Retrieval (SEDAR) at

About The Journal of Commercial Biotechnology

The Journal of Commercial Biotechnology is the definitive international quarterly publication for bioscience business professionals. The Journal is designed specifically for those professionals who need to enhance their knowledge of biotechnology business strategy and management, improve and advance their product development or want to keep up-to-date with current issues and industry trends. Each issue publishes peer-reviewed, authoritative, cutting-edge articles written by the leading practitioners and researchers in the field, addressing topics such as Management, Policy, Finance, Law, Regulation and Bioethics.

Contact Information

Cynapsus Therapeutics
Anthony Giovinazzo
President and CEO
(416) 703-2449 x225
[email protected]

Journal of Commercial Biotechnology
Yali Friedman, Ph.D.
Chief Editor
[email protected]

Forward Looking Statements

This announcement contains "forward-looking statements" within the meaning of applicable Canadian securities legislation. Generally, these forward-looking statements can be identified by the use of forward-looking terminology such as "plans", "expects" or "does not expect", "is expected", "budget", "scheduled", "estimates", "forecasts", "intends", "anticipates" or "does not anticipate", or "believes" or variations of such words and phrases or state that certain actions, events or results "may", "could", "would", "might" or "will be taken", "occur" or "be achieved". Forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of Cynapsus to be materially different from those expressed or implied by such forward-looking statements, including but not limited to those risks and uncertainties relating to Cynapsus’ business disclosed under the heading “Risk and Uncertainties” in “Management's Discussion and Analysis of Operating Results and Financial Condition” for the year ended December 31, 2011, and its other filings with the various Canadian securities regulators which are available online at Although Cynapsus has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements. Cynapsus does not undertake to update any forward-looking statements, except in accordance with applicable securities laws.


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